
What is the route most traveler take in going to Los Angeles from San Francisco
Taking the Golden State Freeway or the Santa Ana Freeway is probably the fastest route from San Francisco to Los Angeles that's the main reason why most travel takes this route.
http://wikitravel.org/en/Driving_in_Los_Angeles_County
Although it's not directly linked to San Francisco, it has 80 miles west of highway this is still the busiest highway for motorist from San Francisco to Los Angeles. It is also one of the oldest freeways in California
http://en.wikipedia.org/wiki/Interstate_5_in_California
This passes through San Diego, Los Angeles, Stockton, Sacramento, and Redding. It is also part of the California Freeway and Expressway System.

